Reserve directly with us
Up to 10% cheaper
than with Booking.com
Check rooms and rates
From91US$ /night
Check-in
31Dec2025Select date
Check-out
01Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

21 Via Di Mezzo, Florence, Italy, 50121
-
Close to the historic old town
Perfect
9.6
/10

Rooms with Essentials

Affittacamere Medusa offers suites with 1 living room, 1 separate bedroom, and 1 bathroom featuring a shower and free toiletries. Rooms include a wardrobe, heating, a desk, bed linen, and towels. Some rooms provide garden views.

Near Key Landmarks

The guest house is in Florence's San Marco-Santissima Annunziata district, a 12-minute walk from San Marco Church. It is 800 meters from Piazza del Duomo and less than 1 km from Florence's city center. Nearby attractions include the Cathedral of Santa Maria del Fiore, Bargello National Museum (1 km), and Ponte Vecchio (1.5 km).

Airport Access

Florence Airport is 10 km from the property. Florence Santa Maria Novella train station is 2 km away.

Basic Amenities

All rooms have air conditioning, heating, and a private bathroom with a bidet and hairdryer. Suites include a wardrobe and a living space.

No Onsite Dining

The guest house does not have an onsite restaurant. Nearby dining options are within walking distance in Florence's city center.

Must-do experiences

  • Visit the Uffizi Gallery early to avoid crowds and enjoy art.
  • Try the lampredotto sandwich at the Mercato di San Lorenzo.
  • Stroll through the Boboli Gardens for stunning views of Florence.
  • Watch the sunset from Piazzale Michelangelo for breathtaking scenery.
  • Discover the ancient village of Fiesole just a short bus ride away.
View all

Choose the Room

From cosy doubles to spacious family suites – all with flexible options, breakfast, and exclusive deals.
Standard Double Suite
2 persons
48 m² 
1 King-size bed
Shower
Heating
Large Double Room
2 persons
25 m² 
1 King-size bed
Shower
Heating
Double or Twin Room Private Bathroom
2 persons
21 m² 
1 King-size bed
Shower
Heating
Double or Twin Room Garden View
2 persons
19 m² 
1 King-size bed
Shower
Heating
Click button to see more rooms
Show all rooms
Show all roomsLess

Check Dates & Room Rates

See what's available for your travel dates

Amenities

Thoughtfully designed amenities for a comfortable & memorable stay

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • No pets allowed
  • Security
  • Adults only
  • Luggage storage
  • Key access

Services

  • Valet parking

Room features

  • Air conditioning
  • Heating

Bathroom

  • Free toiletries
Show more

Location

21 Via Di Mezzo, Florence, Italy, 50121
Map view
21 Via Di Mezzo, Florence, Italy, 50121
Nearby
Museum
Casa Buonarroti
550 m
Synagogue
Sinagoga Synagogue and Jewish Museum
370 m
Restaurants
Hangar
410 m
Via Dei Pepi 43
College Firenze
240 m
Via Pietrapiana 21/R
La Ghiotta
210 m
Via Pietrapiana 7/R
I ragazzi di sipario
420 m
Via Dell'Ulivo 6r All'interno Dello Spazio Alfieri
Panificio Brunori
630 m
Borgo Pinti 16 R
Iyoiyo
550 m
Borgo Pinti 25/R
Mesopotamia
530 m
Piazza Gaetano Salvemini 14
Explore Florence
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Gallerie Degli Uffizi
16 minutes walking
Renowned art museum housing works by masters like Michelangelo. Guided tours enrich the experience, especially on free admission days.
Ponte Vecchio
19 minutes walking
Iconic medieval bridge lined with shops, famed for its jewelry artisans. A must-see for stunning views and rich history.
Piazza del Duomo
13 minutes walking
Breathtaking cathedral square featuring the remarkable Cathedral of Santa Maria del Fiore and other historic structures.
Basilica of Santa Croce in Florence
10 minutes walking
Prominent Franciscan church, known for its beautiful art and tombs of notable figures like Michelangelo and Galileo.
Biking in Florence
10 minutes driving
Scenic bike tours through the city's historic streets. Rentals available nearby; perfect for thrill-seekers to explore rapidly.
Relaxation at Giardino Bardini
19 minutes walking
Serene gardens offering peaceful strolls with stunning city views. A relaxing spot for families and solo travelers alike.
Hangar
5 minutes walking
Trendy venue offering local Italian dishes and delightful atmospheres. Known for its vibrant pizzas and fresh pastas.
La Ghiotta
3 minutes walking
Charming eatery serving classic Tuscan cuisine. Reservations recommended for popular pasta dishes using local ingredients.
Panificio Brunori
8 minutes walking
Family-run bakery famous for its traditional Italian bread and pastries. Ideal for quick bites or delightful sweet treats.
Teatro della Pergola
15 minutes walking
Historic theater showcasing local performances and productions. Family-friendly shows and weekly events add to its charm.
Jazz Club Firenze
10 minutes driving
Popular venue for live jazz music, providing a vibrant nightlife experience. Weekly jam sessions invite guests to unwind.
Getting around
City Centre
Florence10 min  ·  800 m
Airports
Peretola Airport (FLR)14 min  ·  8.9 km
Pisa International Airport - Galileo Galilei (PSA)126 min  ·  83.8 km
Train
Campo di Marte Station15 min  ·  1.2 km
Bus
Bus stop3 min  ·  200 m
Unlock Early-Bird Deals
Grab Exclusive Rates Instantly
Check Rates
Property information and rules
Check-in
from 15:00-18:00
Check-out
until 10 am
Internet
is available in for free.
Pets
Pets are not allowed.

Next best alternative

Consider them for your next trip.
Check-in
31Dec2025Select date
Check-out
01Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near Affittacamere Medusa
The James Suite Hotel Firenze 1564 - Small Luxury Hotels Of The World Interior photo
Mobile-only price

The James Suite Hotel Firenze 1564 - Small Luxury Hotels Of The World

9.8
Perfect35 reviews
41m from property
USD 108USD 97
per night
Casa Rovai Guest House Florence Room photo
Mobile-only price

Casa Rovai Guest House Florence

8.5
Great527 reviews
138m from property
USD 158USD 142
per night
Hotel Monna Lisa Florence Other photo
Mobile-only price

Hotel Monna Lisa Florence

9.0
Perfect2092 reviews
171m from property
USD 88USD 79
per night